期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 8, 页码 3053-3057出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201912739
关键词
asymmetric catalysis; nitrile; oxidative C-H functionalization; quaternary stereocenter; triarylmethane
资金
- National Science Foundation of China [21722204, 21971148, 21432003]
A direct and enantioselective oxidative cross-coupling of racemic 2,2-diarylacetonitriles with electron-rich (hetero)arenes has been described, which allows for efficient construction of triarylmethanes bearing all-carbon quaternary stereocenters with excellent chemo- and enantioselectivity. The reaction has an excellent functional group tolerance, and exhibits a broad scope with respect to both 2,2-diarylacetonitrile and (hetero)arene components. The rich chemistry of the cyano group allows for facile synthesis of other valuable chiral triarylmethanes bearing all-carbon quaternary centers that are otherwise difficult to access.
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