期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 24, 页码 9514-9521出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201916281
关键词
DNA motors; DNA origami; dynamic DNA nanotechnology; fluorescence microscopy; nanomachines
资金
- NSF [DMR 1654485, ECCS-1807568, 1611102, CAREER 1350829, GRFP DGE-1444932]
- NIH [1R21AI135753-01, R01 GM124472]
- Semiconductor Research Corporation (SRC) [2836.002]
- Robert P. Apkarian Integrated Electron Microscopy Core
- Emory University Integrated Cellular Imaging Microscopy Core
- NSH [DMR 1905947]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1611102] Funding Source: National Science Foundation
Inspired by biological motor proteins, that efficiently convert chemical fuel to unidirectional motion, there has been considerable interest in developing synthetic analogues. Among the synthetic motors created thus far, DNA motors that undertake discrete steps on RNA tracks have shown the greatest promise. Nonetheless, DNA nanomotors lack intrinsic directionality, are low speed and take a limited number of steps prior to stalling or dissociation. Herein, we report the first example of a highly tunable DNA origami motor that moves linearly over micron distances at an average speed of 40 nm/min. Importantly, nanomotors move unidirectionally without intervention through an external force field or a patterned track. Because DNA origami enables precise testing of nanoscale structure-function relationships, we were able to experimentally study the role of motor shape, chassis flexibility, leg distribution, and total number of legs in tuning performance. An anisotropic rigid chassis coupled with a high density of legs maximizes nanomotor speed and endurance.
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