期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 10, 页码 3834-3839出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201914868
关键词
configuration determination; indole alkaloids; natural products; organocatalysis; total synthesis
资金
- National Natural Science Foundation of China [21772191, 21572215]
We present the first asymmetric total synthesis and absolute configuration determination of (+)-tronocarpine. The [6.5.7.6.6] pentacyclic core was constructed at an early stage by using a sequential cyclization strategy through a newly developed catalytic asymmetric Michael/aldol cascade to build the aza[3.3.1]-bridged cycle and a tandem reduction/hemiamidation procedure to assemble the seven-membered lactam. The side-chain functionalities were incorporated at a late stage by several appropriately orchestrated manipulations under mild conditions. The synthesis of enantiomerically pure (+)-tronocarpine was achieved through a 20-step longest linear sequence from tryptamine.
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