期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 12, 页码 4846-4850出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201914151
关键词
alkenes; asymmetric catalysis; Lewis acid; oxidation; radicals
资金
- National Natural Science Foundation of China [21625205, 21772127]
Highly efficient asymmetric intermolecular radical-polar crossover reactions were realized by combining a chiral N,N '-dioxide/Ni-II complex catalyst with Ag2O under mild reaction conditions. Various terminal alkenes and indanonecarboxamides/esters underwent radical addition/cyclization reactions to afford spiro-iminolactones and spirolactones with good to excellent yields (up to 99 %) and enantioselectivities (up to 97 % ee). Furthermore, a range of different radical-mediated oxidation/elimination or epoxide ring-opening products were obtained under mild reaction conditions. The Lewis acid catalysts exhibited excellent performance and precluded the strong background reaction.
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