期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 23, 页码 8833-8838出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201914384
关键词
fluorescence; imaging agents; nanoparticles; photothermal therapy; theranostics
资金
- NNSF of China [61525402, 61775095, 21704043, 81872255]
- Jiangsu Provincial key research and development plan [BE2017741]
- Six talent peak innovation team in Jiangsu Province [TD-SWYY-009, WSW041]
- NSF of Jiangsu Province [BK20170990, 17KJB150020]
- Key medical talents fund of Jiangsu Province [2016KJQWZDRC-03]
- China Scholarship Council
- National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH) [ZIA EB000073]
Continuous irradiation during photodynamic therapy (PDT) inevitably induces tumor hypoxia, thereby weakening the PDT effect. In PDT-induced hypoxia, providing singlet oxygen from stored chemical energy may enhance the cell-killing effect and boost the therapeutic effect. Herein, we present a phototheranostic (DPPTPE@PEG-Py NPs) prepared by using a 2-pyridone-based diblock polymer (PEG-Py) to encapsulate a semiconducting, heavy-atom-free pyrrolopyrrolidone-tetraphenylethylene (DPPTPE) with high singlet-oxygen-generation ability both in dichloromethane and water. The PEG-Py can trap the O-1(2) generated from DPPTPE under laser irradiation and form a stable intermediate of endoperoxide, which can then release O-1(2) in the dark, hypoxic tumor microenvironment. Furthermore, fluorescence-imaging-guided phototherapy demonstrates that this phototheranostic could completely inhibit tumor growth with the help of laser irradiation.
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