期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 13, 页码 5108-5115出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201912182
关键词
antioxidants; enzyme mimics; reactive oxygen and nitrogen species; sepsis; single-atom catalysts
资金
- Natural Science Foundation of China [21533008, 91856205, 21871249, 21820102009]
- Key Program of Frontier of Sciences [CAS QYZDJ-SSW-SLH052]
Sepsis, characterized by immoderate production of multiple reactive oxygen and nitrogen species (RONS), causes high morbidity and mortality. Despite progress made with nanozymes, efficient antioxidant therapy to eliminate these RONS remains challenging, owing largely to the specificity and low activity of exploited nanozymes. Herein, an enzyme-mimicking single-atom catalyst, Co/PMCS, features atomically dispersed coordinatively unsaturated active Co-porphyrin centers, which can rapidly obliterate multiple RONS to alleviate sepsis. Co/PMCS can eliminate O-2(.-) and H2O2 by mimicking superoxide dismutase, catalase, and glutathione peroxidase, while removing (OH)-O-. via the oxidative-reduction cycle, with markedly higher activity than nanozymes. It can also scavenge (NO)-N-. through formation of a nitrosyl-metal complex. Eventually, it can reduce proinflammatory cytokine levels, protect organs from damage, and confer a distinct survival advantage to the infected sepsis mice.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据