期刊
ANALYTICAL SCIENCES
卷 36, 期 1, 页码 127-133出版社
SPRINGERNATURE
DOI: 10.2116/analsci.19P271
关键词
Electrochemical sensor; doxorubicin hydrochloride; nickel hexacyanoferrate; double hydroxides
资金
- Doctor Fund of Shanxi Normal University [0505/02070468]
A highly sensitive and selective electrochemical sensor has been fabricated by the electrodepositing of nickel hexacyanoferrate (NiHCF) on a Ni-Al layered double hydroxides (Ni-Al-LDH) modified Au electrode for the quantification of doxorubicin hydrochloride (DOX). The characterization of synthesized nanomaterials has been conducted by scanning electron microscopy, energy dispersive X-ray spectroscopy and electrochemical methods. The synergistic effect of NiHCF and Ni-Al-LDH not only excellently improves the performance of DOX electro-reduction, but also promotes electron transfer between DOX and the NiHCF/Ni-Al-LDH/Au sensor. The differential pulse voltammetric response of the NiHCF/Ni-Al-LDH/Au sensor shows a linear relationship with the concentration of DOX in the range of 1.0 x 10(-8) - 6.2 x 10(-6) mol L-1, a limit of detection of 1.9 x 10(-9) mol L-1 (S/N=3) and a sensibility of 14.71 A mol L-1 cm(-2). The developed sensor exhibits good sensitivity, reproducibility, anti-interference and a long-term stability property. Furthermore, the NiHCF/Ni-Al-LDH/Au sensor has been successfully applied to determine DOX in biological samples and human blood serum samples.
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