期刊
ANALYTICAL CHEMISTRY
卷 92, 期 5, 页码 3517-3521出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.0c00054
关键词
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资金
- National Natural Science Foundation of China [21977078]
- Natural Science Foundation of Jiangsu Province [BK20181429]
- Project of Scientific and Technological Infrastructure of Suzhou [SZS201708]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions
Six mitochondria/lysosomes self-targetable and viscosity-sensitive dyes (1a-1f) were developed via simple structure modification on cyanine-derived dyes. They all showed remarkable OFF-ON fluorescent response to viscosity in the near- infrared region (652-690 nm) and exhibited good linear relationship with solution viscosity. The transient absorption spectra were used to evaluate the excited-state lifetime of dye la in different viscosity environments. Furthermore, cellular imaging assays indicated that different derivatives (1a-1f) with the same chromophore core exhibited different organelle-targeting abilities. Among them, dyes 1a-1c could sense lysosomal viscosity fluctuations while dyes Id-If could be applied in mitochondrial viscosity detections.
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