期刊
ANALYTICA CHIMICA ACTA
卷 1093, 期 -, 页码 61-74出版社
ELSEVIER
DOI: 10.1016/j.aca.2019.09.078
关键词
Covalent organic frameworks; Magnetic solid phase extraction; Postsynthetic modifications; Boronate affinity; Monoamine neurotransmitters
资金
- National Natural Science Foundation of China [21575114, 21775121]
- Shaanxi Provincial Key Research and Development Program [2018KW-033]
- Xi'an Science and Technology Plan Project [201805041YD19CG25(3)]
Covalent organic frameworks (COFs) have been increasingly employed in separation science, including sample preparation. Herein we fabricated the amino bearing core-shell structured COFs nanospheres [Fe3O4@TpBD(NH2)(2)], and a novel magnetic boronate affinity adsorbent was synthesized by post-synthetic modification of the Fe3O4@TpBD(NH2)(2)] with 2-formylphenylboronic acid. The magnetic boronate affinity adsorbent possesses fast magnetic response and high binding capacity up to 1037 mu mol g(-1) for dopamine. Besides, it was used as an adsorbent for extraction of urinary monoamine neurotransmitters at neutral pH. A method for detection of the monoamine neurotransmitters was developed by coupling the magnetic solid phase extraction with high-performance liquid chromatography-fluorescence detection. Under the optimized conditions, a good analytical method was obtained in the linear dynamic range of 2-200 ng mL(-1) with R-2 between 0.9917 and 0.9966, with low limit of detection (0.31-0.54 ng mL (-1)) and limit of quantification (1.04-1.80 ng mL(-1)). The recoveries of the monoamine neurotransmitters were in the range of 86.3-115%, with relative standard deviations of 2.34-10.5% (intra-day) and 2.84-14.4% (inter-day). The method was successfully applied to the determination of the monoamine neurotransmitters in human urine samples. This work is of great importance for preparing functionalized core-shell structured magnetic covalent organic framework nanospheres, it also demonstrates the feasibility of the functionalized magnetic COFs as adsorbents in sample pretreatment. (C) 2019 Elsevier B.V. All rights reserved.
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