期刊
BIOPROCESS AND BIOSYSTEMS ENGINEERING
卷 38, 期 7, 页码 1243-1249出版社
SPRINGER
DOI: 10.1007/s00449-015-1365-z
关键词
Silver nanoparticles; Pseudomonas putida; ROS; Lipid peroxidation; Toxicity
资金
- Science and Engineering Research Board, Department of Science and Technology, Government of India [SB/FT/LS-281/2012]
Silver nanoparticles (Ag NPs) are being increasingly used in many consumer products owing to their excellent antimicrobial properties. The continuous use of Ag NPs in consumer products will lead to environmental release. The present study evaluated the toxic effects and the possible underlying mechanism of Ag NPs on Pseudomonas putida. Ag NP exposure inhibited growth of the cells. Increased lipid peroxidation occurred coincident with suppression of the antioxidant defense system. Ag NP exposure caused reactive oxygen species (ROS) production, glutathione depletion and inactivation of the antioxidant enzyme superoxide dismutase, catalase and glutathione reductase. The addition of superoxide dismutase or pretreatment of P. putida with N-acetyl cysteine that quenches ROS reduced toxicity of the NPs.
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