期刊
ALZHEIMERS & DEMENTIA
卷 16, 期 1, 页码 200-208出版社
ELSEVIER SCIENCE INC
DOI: 10.1002/alz.12008
关键词
Alzheimer's disease; APOE4; dementia; genetic susceptibility; herpes virus; prevention
资金
- Fondation pour la Recherche Medicale
- Caisse Nationale Maladie des Travailleurs Salaries
- Direction Generale de la Sante
- MGEN
- Institut de la Longevite
- Conseils Regionaux d'Aquitaine et Bourgogne
- Fondation de France
- Ministry of Research-INSERM Programme Cohortes et collections de donnees biologiques
- Agence Nationale de la Recherche ANR
- Fondation Plan Alzheimer (FCS 2009-2012)
- Caisse Nationale de Solidarite pour l'Autonomie (CNSA)
- Roche
- Fondation Plan Alzheimer (AAP 2016)
Introduction: Numerous results suggest the implication of infectious agents in the onset of Alzheimer's disease (AD). Methods: In the Bordeaux-3C prospective cohort, we assessed the impact of herpes simplex virus type 1 (HSV-1) infection on the incidence of AD according to apolipoprotein E (APOE) status, a genetic susceptibility factor. Cox models were performed to estimate the 10-year risk of AD associated with anti-HSV antibodies in 1037 participants according to APOE4 status. Results: Among APOE4 carriers, subjects for whom the frequency of HSV-1 reactivation is supposed to be high, that is, immunoglobulin M (IgM) positive or elevated levels of IgG, had an increased risk of AD with adjusted hazard ratios (H Rs) of 3.68 (1.08-12.55) and 3.28 (1.19-9.03). respectively. No significant association was found in APOE4-negative subjects. Discussion: These results, in accordance with a solid pathophysiological rationale, suggest a role for HSV-1 in AD development among subjects with a genetic susceptibili factor, the APOE4 allele.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据