4.6 Article

Successful aging: insights from proteome analyses of healthy centenarians

期刊

AGING-US
卷 12, 期 4, 页码 3502-3515

出版社

IMPACT JOURNALS LLC
DOI: 10.18632/aging.102826

关键词

proteomics; healthy aging; elderly; senescence; immune system

资金

  1. University of Alcala [FPI2016]
  2. Spanish Ministry of Science, Innovation and Universities
  3. Fondos FEDER (Fondo de Investigaciones Sanitarias [FIS]) [PI15/00558, PI18/00139, PI18/00207]
  4. MINECO [BIO2015-67580-P]
  5. Fundacio Marato TV3 [122/C/2015]
  6. la Caixa Banking Foundation [HR17-00247]
  7. Spanish Ministry of Economy and Science, Innovation and Universities
  8. Pro-CNIC Foundation
  9. Severo Ochoa Center of Excellence (MINECO) [SEV-2015-0505]
  10. AXA Research Fund
  11. Fondation partenariale Sorbonne Universite
  12. Fondation pour la Recherche sur Alzheimer, Paris, France
  13. Universidad Europea de Madrid [2017/UEM05]

向作者/读者索取更多资源

Healthy aging depends on a complex gene-environment network that is ultimately reflected in the expression of different proteins. We aimed to perform a comparative analysis of the plasma proteome of healthy centenarians (n=9, 5 women, age range 100-103 years) with a notably preserved ambulatory capacity (as a paradigm of 'successful' aging), and control individuals who died from a major age-related disease before the expected life expectancy (n=9, 5 women, age range: 67-81 years), and while having impaired ambulatory capacity (as a paradigm of 'unsuccessful' aging). We found that the expression of 49 proteins and 86 pathways differed between the two groups. Overall, healthy centenarians presented with distinct expression of proteins/pathways that reflect a healthy immune function, including a lower pro-inflammatory status (less 'inflammaging' and autoimmunity) and a preserved humoral immune response (increased B cell-mediated immune response). Compared with controls, healthy centenarians also presented with a higher expression of proteins involved in angiogenesis and enhanced intercellular junctions, as well as a lower expression of proteins involved in cardiovascular abnormalities. The identification of these proteins/pathways might provide new insights into the biological mechanisms underlying the paradigm of healthy aging.

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