期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 362, 期 8, 页码 1674-1678出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.202000092
关键词
Halogen bond; Mannich-type reaction; Unnatural amino acid; alpha-Ketiminoester; Iodine
Chiral organic base catalyst with halogen bond donor functionality catalyzed asymmetric Mannich-type reaction of malononitrile with alpha-ketiminoesters to produce alpha,alpha-disubstituted alpha-amino acid derivatives in good yields with high enantioselectivities. The malononitrile-derived amino acid was smoothly transformed to chiral aminomalonate without loss of ee.
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