Catalytic Asymmetric Mannich-Type Reaction of Malononitrile with N-Boc α-Ketiminoesters Using Chiral Organic Base Catalyst with Halogen Bond Donor Functionality

Chiral organic base catalyst with halogen bond donor functionality catalyzed asymmetric Mannich-type reaction of malononitrile with alpha-ketiminoesters to produce alpha,alpha-disubstituted alpha-amino acid derivatives in good yields with high enantioselectivities. The malononitrile-derived amino acid was smoothly transformed to chiral aminomalonate without loss of ee.