期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 362, 期 5, 页码 1058-1063出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201901413
关键词
bifunctional phosphonium salt catalysis; spiro-chroman-thiazolone; [2+4] annulation; 5-alkenyl thiazolones; para-quinone methides
资金
- National Natural Science Foundation of China [21702139]
- 1000-Youth Talents Program [YJ201702]
- Fundamental Research Funds for the Central Universities
The enantioselective formal [2+4] annulation of 5-alkenyl thiazolones with hydroxyl-substituted para-quinone methides was disclosed by dipeptide-based phosphonium salt catalysts. A wide range of functionalized spiro-chroman-thiazolone molecules bearing three contiguous 3 degrees and/or 4 degrees stereocenters were readily constructed in high yields with excellent stereoselectivities (>20:1 dr and up to >99.9% ee) under low catalyst loading and mild reaction conditions. The practicality and utility of this protocol were demonstrated by the scaled-up preparation and elaborations of product.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据