期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 362, 期 6, 页码 1317-1322出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201901550
关键词
Benzofurans; Heck Reaction; beta-Iodovinyl sulfones; Naphthofurans; oxa-Michael addition
资金
- CSIR-EMR-II, New Delhi [02(0340)/18/EMRII]
- DST Inspire
- CSIR-EMR-II, New Delhi
The palladium-catalyzed annulation between beta-iodovinyl sulfones and 2-halophenols or 1-bromo-2-naphthol or 2-bromo-3-pyridinol is presented. The annulation process involving oxa-Michael addition-elimination and intramolecular Heck reaction leading to form 2,3-disubstituted benzofurans (aryl benzofuryl sulfones) in good to high yields. The regioselective tandem construction of C-O and C-C bonds has been achieved with a variety of substitution patterns. Moreover, the tandem process is reliable at gram-scale reactions and a plausible mechanism is also proposed.
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