S-(Diethyl phosphonodifluoromethyl)Benzenesulfonothioate: A New Reagent for the Synthesis of SCF2PO(OEt)2-containing Molecules

In this manuscript, the synthesis of an original SCF2PO(OEt)(2)-containing reagent was depicted. Thanks to the unique properties of this newly-designed source, an unprecedented transformation with aldehydes was conducted under radical conditions, offering an access to value-added fluoroalkylthio compounds. Preliminary mechanistic studies were conducted and supported a radical reaction mechanism. Remarkably, thiol and disulfide derivatives turned out to be suitable coupling partners in a transition metal free transformation towards the synthesis of difficult-to-synthesize unsymmetrical disulfides. Finally, the difunctionalization of 4-phenyl-butene was investigated using this reagent.