期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 362, 期 2, 页码 314-319出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201901185
关键词
continuous flow; heterogeneous catalysis; hydrogenation; immobilization; organocatalysis
资金
- DARPA Make-It program [ARO W911NF-16-2-0023]
- FWO (PhD Fellowship of the Research Foundation - Flanders)
Monolithic and packed-bed reactors featuring immobilized catalysts are well-precedented in continuous flow synthesis but can suffer from adverse pressure drops during use due to their small pore sizes and/or structural changes. Herein, we overcome this challenge with the synthesis of a structurally robust silica-based monolith featuring pore sizes on the millimeter scale. The 3-dimensional solid support structure is constructed from a polystyrene foam-based template and features a functional group handle that can be modified to display a reactive catalyst. Here we functionalize the support with palladium(0) for hydrogenation reactions and a modified proline catalyst for the alpha functionalization of aldehydes. Both reactors showed good activity and excellent catalytic longevity when utilized under continuous flow conditions.
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