期刊
ADVANCED MATERIALS
卷 32, 期 6, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201904598
关键词
cardiac tissues; cellular organization; hydrogels; magnetic nanoparticles; patterning
类别
资金
- COMSOL Ltd.
- European Union's Horizon 2020 Research and Innovation Programme through the Marie Sklodowska-Curie Individual Fellowship Magnetic HEART [659175]
- British Heart Foundation [FS/16/76/32409, FS/15/33/31608]
- UK Regenerative Medicine Platform Acellular/Smart Materials -3D Architecture [MR/R015651/1]
- Rosetrees Trust
- Engineering and Physical Sciences Research Council (EPSRC) [EP/R004994/1]
- British Heart Foundation Centre of Research Excellence [RE/13/430184]
- Medical Research Council (MRC) [MR/R026416/1]
- BHF Centre for Cardiac Regeneration at Imperial College London [RM/17/1/33377]
- Wellcome Trust [098411/Z/12/Z]
- Kusuma Trust UK
- Marie Curie Actions (MSCA) [659175] Funding Source: Marie Curie Actions (MSCA)
- MRC [MR/R026416/1, MR/R015651/1] Funding Source: UKRI
The ability to manipulate cellular organization within soft materials has important potential in biomedicine and regenerative medicine; however, it often requires complex fabrication procedures. Here, a simple, cost-effective, and one-step approach that enables the control of cell orientation within 3D collagen hydrogels is developed to dynamically create various tailored microstructures of cardiac tissues. This is achieved by incorporating iron oxide nanoparticles into human cardiomyocytes and applying a short-term external magnetic field to orient the cells along the applied field to impart different shapes without any mechanical support. The patterned constructs are viable and functional, can be detected by T-2*-weighted magnetic resonance imaging, and induce no alteration to normal cardiac function after grafting onto rat hearts. This strategy paves the way to creating customized, macroscale, 3D tissue constructs with various cell-types for therapeutic and bioengineering applications, as well as providing powerful models for investigating tissue behavior.
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