期刊
ACS NANO
卷 14, 期 2, 页码 2183-2190出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.9b09032
关键词
aggregation-induced emission; photosensitizer; self-assembly; sabutoclax; hybrid nanosphere; photodynamic therapy
类别
资金
- Singapore National Research Foundation [R279000-444-281, R279-000-483-281]
- National University of Singapore [R279-000-482-133]
Photodynamic therapy (PDT) has been a well-accepted clinical treatment for malignant tumors owing to its noninvasiveness and high spatiotemporal selectivity. However, the efficiency of PDT is still severely hindered by an inherent aggregation-caused quenching (ACQ) effect of traditional photosensitizers (PSs), the presence of B-cell lymphoma 2 (Bcl-2), an antiapoptosis protein in cells, and hypoxia in the tumor microenvironment. To address these issues, hybrid nanospheres containing Fe3+, aggregation-induced emission (ME) PS, and Bcl-2 inhibitor of sabutoclax were constructed via coordination-driven self-assembly in aqueous media. Once the hybrid nanospheres are taken up by tumor cells, intracellular O-2 concentration is observed to increase via Fenton reaction driven by Fe3+, whereas intracellular PDT resistance of the ME PS was mitigated by sabutoclax. The design of the multifunctional hybrid nanospheres demonstrates a prospective nanoplatform for image-guided enhanced PDT of tumors.
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