期刊
ACS NANO
卷 14, 期 2, 页码 2053-2062出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.9b08660
关键词
magnetic particle imaging; cubic iron oxide nanoparticle; bone mesenchymal stem cell; stem cell tracking; hindlimb ischemia
类别
资金
- National Key Research and Development Program of China [2016YFA0203600, 2017YFA0205200, 2016YFA0100902]
- National Natural Science Foundation of China [31822019, 51703195, 91859116, 81871442, 61876178]
- One Belt and One Road International Cooperation Project from the Key Research and Development Program of Zhejiang Province [2019C04024]
- National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China [2018ZX09711002]
- Fundamental Research Funds for the Central Universities [2019XZZX004IS]
- Zhejiang Provincial Natural Science Foundation of China [LGF19C100002]
Stem cell therapies are increasingly recognized as the future direction of regenerative medicine, but the biological fate of the administrated stem cells remains a major concern for clinical translation, which calls for an approach to efficiently monitoring the stem cell behaviors in vivo. Magnetic particle imaging (MPI) is an emerging technology for cell tracking; however, its utility has been largely restricted due to the lack of optimal magnetic nanoparticle tracers. Herein, by controlled engineering of the size and shape of magnetic nanoparticles tailored to MPI physics theory, a specialized MPI tracer, based on cubic iron oxide nanoparticles with an edge length of 22 nm (CIONs-22), is developed. Due to the inherent lower proportion of disordered surface spins, CIONs-22 exhibit significantly larger saturation magnetization than that of spherical ones, while they possess similar saturation magnetization but smaller coercivity compared to larger-sized CIONs. These magnetic properties of CIONs-22 warrant high sensitivity and resolution of MPI. With their efficient cellular uptake, CIONs-22 exhibit superior MPI performance for stem cell labeling and tracking compared to the commercialized tracer Vivotrax. By virtue of these advantages, CIONs-22 enable real-time and prolonged monitoring of the spatiotemporal trajectory of stem cells transplanted to hindlimb ischemia mice, which demonstrates the great potential of CIONs-22 as MPI tracers to advance stem cell therapies.
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