期刊
ACS NANO
卷 14, 期 2, 页码 2276-2284出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.9b09312
关键词
DNA; peptide; block copolymer; self-assembly; nanosheet; nanofiber
类别
资金
- National Research Foundation of Korea - Korea government [NRF-2018R1A2B3001049, NRF-2017R1A5A1015365]
- Ewha Womans University
- Basic Science Research Program through the National Research Foundation of Korea - Ministry of Education [NRF-2019RMA1A01044158]
We report the rational design and fabrication of unusual low-dimensional DNA nanostructures through programmable and sequence-specific peptide interactions. Dual-bioactive block copolymers composed of DNA and amino acid-based polymers (DNA-b-poly(amino acid)) were synthesized by coupling oligonucleotides to phenylalanine (Phe)-based polymers. Unlike prototypical DNA block copolymers, which typically form simple spherical micelles, DNA-b-poly(amino acid) assemble into various low-dimensional structures such as nanofibers, ribbons, and sheets through controllable amino acid interactions. Moreover, DNA-b-poly(amino acid) assemblies can undergo protease-induced fiber-to-sheet shape transformations, where the morphology change is dictated by the type of enzymes and amino acid sequences. The peptide-based self-assembly reported here provides a programmable approach to fabricate dynamic DNA assemblies with diverse and unusual low-dimensional structures.
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