期刊
ACS NANO
卷 14, 期 2, 页码 2024-2035出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.9b08587
关键词
platelet biomimetics; nitric oxide; drug delivery; magnetic materials; stimuli-responsive materials
类别
资金
- National Key Research and Development Program of China [2018YFA0704103, 2017YFA0104302]
- National Natural Science Foundation of China [81971750, 61821002]
- National Natural Science Foundation of Jiangsu [BK20191266]
- Six Talent Peaks Project of Jiangsu Province [2017-SWYY-006]
- Zhong Ying Young Scholar of Southeast University
- Fundamental Research Funds for the Central Universities
Early diagnosis and treatment of acute ischemic stroke poses a significant challenge due to its suddenness and short therapeutic time window. Human endogenous cells derived biomimetic drug carriers have provided new options for stroke theranostics since these cells have higher biosafety and targeting abilities than artificial carriers. Inspired by natural platelets (PLTs) and their role in targeting adhesion to the damaged blood vessel during thrombus formation, we fabricated a biomimetic nanocarrier comprising a PLT membrane envelope loaded with L-arginine and gamma-Fe2O3 magnetic nanoparticles (PAMNs) for thrombus-targeted delivery of L-arginine and in situ generation of nitric oxide (NO). Results demonstrate that the engineered 200 nm PAMNs inherit the natural properties of the PLT membrane and achieve rapid targeting to ischemic stroke lesions under the guidance of an external magnetic field. Subsequent to the release of L-arginine at the thrombus site, endothelial cells produce NO, which promotes vasodilation to disrupt the local PLT aggregation. Rapid targeting of PAMNs to stroke lesions as well as in situ generation of NO prompts vasodilation, recovery of blood flow, and reperfusion of the stroke microvascular. Thus, these PLT membrane derived nanocarriers are diagnostically beneficial for localizing stroke lesions and a promising modality for executing therapies.
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