期刊
ACS NANO
卷 14, 期 1, 页码 142-152出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.9b05660
关键词
magnetophoresis; tumor; magnetic; nanoparticles; penetration
类别
资金
- NIH/NIBIB [R21 EB023989]
- NIH/NCI [R01 CA181429]
- NIH/NINDS [T32 NS091006]
- U. of Penn. University Research Foundation Award
Drug delivery to solid tumors is hindered by hydrostatic and physical barriers that limit the penetration of nanocarriers into tumor tissue. When exploiting the enhanced permeability and retention (EPR) effect for passive targeting of nanocarriers, the increased interstitial fluid pressure and dense extracellular matrix in tumors limits the distribution of the nanocarriers to perivascular regions. Previous strategies have shown that magnetophoresis enhances accumulation and penetration of nanoparticles into solid tumors. However, because magnetic fields fall off rapidly with distance from the magnet, these methods have been limited to use in superficial tumors. To overcome this problem, we have developed a system comprising two oppositely polarized magnets that enables the penetration of magnetic nanocarriers into more deeply seeded tumors. Using this method, we demonstrate a 5-fold increase in the penetration and a 5-fold increase in the accumulation of magnetic nanoparticles within solid tumors compared to EPR.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据