期刊
ACS NANO
卷 14, 期 1, 页码 129-141出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.9b04898
关键词
cancer therapy; nuclear imaging; nanoencapsulation; filled carbon nanotubes; radiooncology; nanooncology
类别
资金
- European Union [290023]
- Worldwide Cancer Research [12-1054]
- MEYS [LTC18039]
- Agaur [2017 SGR 581]
- Spanish Ministry of Economy and Competitiveness, through the Severo Ochoa Programme for Centres of Excellence in RD [SEV-2015-0496, SEV-2017-0706]
- Centre National de la Recherche Scientifique (CNRS)
- Agence Nationale de la Recherche (ANR) through the LabEx project Chemistry of Complex Systems [ANR-10-LABX-0026_CSC]
- International Center for Frontier Research in Chemistry (icFRC)
- MEYS CR
- EU-ESIF in the frame of Operational Programme Research Development and Education-project Pro-NanoEnviCz [CZ.02.1.01/0.0/0.0/16_013/0001821]
Radiation therapy along with chemotherapy and surgery remain the main cancer treatments. Radiotherapy can be applied to patients externally (external beam radiotherapy) or internally (brachytherapy and radioisotope therapy). Previously, nanoencapsulation of radioactive crystals within carbon nano-tubes, followed by end-closing, resulted in the formation of nanocapsules that allowed ultrasensitive imaging in healthy mice. Herein we report on the preparation of nanocapsules initially sealing cold isotopically enriched samarium (Sm-152), which can then be activated on demand to their hot radioactive form (Sm-153) by neutron irradiation. The use of cold isotopes avoids the need for radioactive facilities during the preparation of the nanocapsules, reduces radiation exposure to personnel, prevents the generation of nuclear waste, and evades the time constraints imposed by the decay of radionuclides. A very high specific radioactivity is achieved by neutron irradiation (up to 11.37 GBq/mg), making the hot nanocapsules useful not only for in vivo imaging but also therapeutically effective against lung cancer metastases after intravenous injection. The high in vivo stability of the radioactive payload, selective toxicity to cancerous tissues, and the elegant preparation method offer a paradigm for application of nanomaterials in radiotherapy.
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