期刊
ACS NANO
卷 14, 期 3, 页码 3546-3562出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.9b09871
关键词
antibiofilm; polydopamine; nitric oxide; photothermal therapy; photodynamic therapy
类别
资金
- Fundamental Research Funds for the Central Universities [2019CDXYSG0004, 2018CDXYSW0023, 2018CDYJSY0055]
- National Natural Science Foundation of China [51825302, 21734002, 51673032]
- State Key Project of Research and Development [2016YFC1100300, 2017YFB0702603]
- Chongqing Research Program of Technological Innovation and Application Demonstration [cstc2018jscx-msybX0299]
Photothermal treatment (PTT) involving a combination of therapeutic modalities recently emerged as an efficient alternative for combating biofilm. However, PTT-related local high temperature may destroy the surrounding healthy tissues. Herein, we present an all-in-one phototherapeutic nanoplatform consisting of L-arginine (L-Arg), indocyanine green (ICG), and mesoporous polydopamine (MPDA), namely, AI-MPDA, to eliminate the already-formed biofilm. The fabrication process included surface modification of MPDA with L-Arg and further adsorption of ICG via pi-pi stacking. Under near-infrared (NIR) exposure, AI-MPDA not only generated heat but also produced reactive oxygen species, causing a cascade catalysis of L-Arg to release nitric oxide (NO). Under NIR irradiation, biofilm elimination was attributed to the NO-enhanced photodynamic therapy and low-temperature PTT (<= 45 degrees C). Notably, the NIR-triggered all-in-one strategy resulted in severe destruction of bacterial membranes. The phototherapeutic AI-MPDA also displayed good cytocompatibility. NIR-irradiated AI-MPDA nanoparticles not only prevented bacterial colonization but also realized a rapid recovery of infected wounds. More importantly, the all-in-one phototherapeutic platform displayed effective biofilm elimination with an efficiency of around 100% in a abscess formation model. Overall, this low-temperature phototherapeutic platform provides a reliable tool for combating already-formed biofilms in clinical applications.
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