4.8 Article

Gold Nanorods and Nanoprisms Mediate Different Photothermal Cell Death Mechanisms In Vitro and In Vivo

期刊

ACS APPLIED MATERIALS & INTERFACES
卷 12, 期 12, 页码 13718-13730

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c02022

关键词

gold nanoparticles; hyperthermia; model organism; apoptosis; necroptosis; Hydra vulgaris

资金

  1. European Union's Horizon 2020 research and innovation program (Marie Sklodowska-Curie grant) [660228]
  2. Spanish Juan de la Cierva Program [IJCI-2016-30520]
  3. Marie Curie Actions (MSCA) [660228] Funding Source: Marie Curie Actions (MSCA)

向作者/读者索取更多资源

Photothermal therapy (PTT) is an efficient method of inducing localized hyperthermia and can be achieved using gold nanoparticles as photothermal agents. However, there are many hurdles to get over before this therapy can safely reach the clinics, including nanoparticles' optimal shape and the accurate prediction of cellular responses. Here, we describe the synthesis of gold nanorods and nanoprisms with similar surface plasmon resonances in the near-infrared (NIR) and comparable photothermal conversion efficiencies and characterize the response to NIR irradiation in two biological systems, melanoma cells and the small invertebrate Hydra vulgaris. By integrating animal, cellular, and molecular biology approaches, we show a diverse outcome of nanorods and nanoprisms on the two systems, sustained by the elicitation of different pathways, from necrosis to programmed cell death mechanisms (apoptosis and necroptosis). The comparative multilevel analysis shows great accuracy of in vivo invertebrate models to predict overall responses to photothermal challenging and superior photothermal performance of nanoprisms. Understanding the molecular pathways of these responses may help develop optimized nanoheaters that, safe by design, may improve PTT efficacy for clinical purposes.

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