期刊
ACS APPLIED MATERIALS & INTERFACES
卷 12, 期 2, 页码 1963-1972出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b14958
关键词
2D metal-organic framework; photodynamic therapy; mitochondrial targeting; reactive oxygen species; nanozymes
资金
- Natural Science Foundation of Jiangsu Province [BK20190756]
- National Natural Science Foundation of China [21905138, 21371031, 21628101]
- China Postdoctoral Science Foundation [2019M651841]
- International S&T Cooperation Program of China [2015DFG42240]
- Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions
Photodynamic therapy (PDT) as a noninvasive therapy mode has attracted considerable attention in the field of oncotherapy. However, the PDT efficacy is restricted either by the tumor hypoxia environment or the inherent properties of photosensitizers (PSs) including bad water solution, photobleaching, and easy aggregation. Herein, we designed and synthesized a new two-dimensional (2D) metal-organic framework, Sm-tetrakis(4-carboxyphenyl)porphyrin (TCPP) nanosheets, by assembling transition metal ions (Sm3+) and PSs (TCPP), on which the catalase (CAT)-mimicking platinum nanozymes were then in situ grown for sufficient oxygen supply during PDT. The prepared Sm-TCPP with nanoplate morphology (similar to 100 nm in diameter) and ultrathin thickness (<10 nm) showed significantly enhanced O-1(2) generation capacity due to the improved physicochemical properties and the enhanced intersystem crossing from heavy Sm nodes. More importantly, the CAT -mimicking Pt nanozyme on the Sm-TCPP nanosheets could effectively convert over-expressed H2O2 in the tumor microenvironment into O-2 to relieve tumor hypoxia. Further, the triphenylphosphine (TPP) molecule was introduced to Sm-TCPP-Pt to develop a mitochondrion-targeting and O-2 self-supply PDT system. The in vitro and in vivo experimental results based on the MCF-7 breast cancer model revealed that Sm-TCPP-Pt/TPP could relieve tumor hypoxia and the generated reactive oxygen species nearby intracellular mitochondria significantly induced cell apoptosis. This study offers an engineering strategy to integrate 2D PS-based metal-organic frameworks and nanozymes into a nanoplatform to surmount the pitfalls of traditional PDT.
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