期刊
ACS APPLIED MATERIALS & INTERFACES
卷 12, 期 1, 页码 1799-1805出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b16702
关键词
early detection; optical microfiber; biosensor; interfacial sensitization; in serum
资金
- National Natural Science Foundation of China [51773084, U1701268]
- Guangdong Natural Science Foundation [2019A1515011278]
- Special Funds for the Cultivation of Guangdong College Students' Scientific and Technological Innovation (Climbing Program Special Funds) [pdjh2019a0054]
The detection of carcinoembryonic antigen (CEA)-related cell adhesion molecules 5 (CEACAM5) is significant in cancer prewarning. Early diagnosis can effectively alleviate the danger of cancer. Point-of-care testing (POCT) has become a competitive technology for early detection. Fiber optic biosensors have great potential as POCT tools. However, their limits of detection (LODs) are not sufficient to afford ultralow concentration detection at the early stage. Herein, this work presents an optical microfiber sensor functionalized by a polystyrene@gold nanosphere (PS@Au nanosphere) interface for a synergistic sensitization effect to detect the ultralow CEACAM5 concentrations in serum at the early stage. The sensor's LOD achieves 3.54 x 10(-17) M in pure solution and 5.27 x 10(-16) M in serum, with the sensitization effect coupled with surface area enlargement and electromagnetic enhancement of interface. This LOD is about 6 orders of magnitude lower than that of current methods. It can be employed to detect the biomarkers at ultralow concentrations present in serum in the early stages of cancer. As the interfacial synergistic sensitization strategy is suitable for refractive index (RI)-based optical transducers, this work provides new opportunities to employ fiber optic biosensors as effective POCT tools.
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