期刊
ACS APPLIED MATERIALS & INTERFACES
卷 12, 期 4, 页码 5050-5057出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b18693
关键词
curcumin; two-photon polymerization; antibacterial materials; free-radical polymerization; reactive oxygen species
资金
- French Research National Agency (ANR)
- UPEC
- ICMPE
- Ministry of Education, Science, Research and Sport of the Slovak Republic
- Scientific Grant Agency of the Slovak Republic (VEGA Project) [1/0026/18]
- Ministere de l'Education Nationale, de l'Enseignement Superieur et de la Recherche, Universite Paris-Sud Paris-Saclay [571]
- Centre de Photonique Biomedicale of the Centre Laser de PUniversite Paris-Sud (Orsay, France) [CLUPS/LUMAT FR2764]
A new antibacterial strategy is reported based on two-photon fabrication of three-dimensional curcumin-embedded mu-cages. Such devices were designed to entrap and kill Staphylococcus aureus bacteria upon visible light irradiation. The proposed concept mainly relies on the pivotal role of curcumin, which is sequentially used as a two-photon active free radical initiator and as a photogenerator of reactive oxygen species within the cage mu-volumes. We show that these mu-cages exhibit extremely high antimicrobial properties, leading to 95% bacteria mortality after only 10 min visible irradiation. A preconcentration mechanism of photogenerated oxygen species is proposed to account for this highly performing bactericidal effect whose virulence can be strikingly switched on by increasing the light exposure time from 5 to 10 min.
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