期刊
ACS APPLIED MATERIALS & INTERFACES
卷 12, 期 8, 页码 9107-9117出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b23413
关键词
copper sulfide nanoparticles; second near-infrared window; nanogels; MR/PA dual-modal imaging; photothermal therapy
资金
- Sino-German Center for Research Promotion [GZ1505]
- National Natural Science Foundation of China [81761148028]
- Science and Technology Commission of Shanghai Municipality [19410740200, 19XD1400100, 18520750400]
- Fundamental Research Funds for the Central Universities
- FCT-Fundacao para a Ciancia e a Tecnologia [UIDB/00674/2020, UIDP/00674/2020]
- ARDITI-Agancia Regional para o Desenvolvimento da Investigacao Tecnologia e Inovacao, through the project Centro de Quimica da Madeira-CQM+ (Madeira 14-20 Program) [M1420-01-0145-FEDER-000005]
The second near-infrared (NIR-II, 1000-1700 nm) light-based diagnosis and therapy have received extensive attention for neoplastic disease treatments because of the fact that light in the NIR-II window possesses less photon scattering along with deeper tissue penetration than that in the NIR-I (700-950 nm) window. Herein, we present a Gd- and copper sulfide (CuS)-integrated nanogel (NG) platform for magnetic resonance (MR)/photoacoustic (PA) imaging-guided tumor-targeted photothermal therapy (PTT). In our approach, we prepared cross-linked polyethylenimine (PEI) NGs via an inverse emulsion method, modified the PEI NGs with Gd chelates, targeting ligand folic acid (FA) through a polyethylene glycol (PEG) spacer and 1,3-propanesultone, and finally loaded CuS nanoparticles (NPs) within the functional NGs. The as-synthesized Gd/CuS@PEI-FA-PS NGs with a mean size of 85 nm exhibit a good water dispersibility and protein resistance property, admirable r(1) relaxivity (11.66 mM(-1) s(-1)), excellent NIR-II absorption feature, high photothermal conversion efficiency (26.7%), and FA-mediated targeting specificity to cancer cells overexpressing FA receptor (FAR). With these properties along with the good cytocompatibility, the developed Gd/CuS@PEI-FA-PS NGs enable MR/PA dual-mode imaging-guided targeted PTT of FAR-overexpressing tumors under the irradiation of an NIR-II (1064 nm) laser. The designed Gd/CuS@PEI-FA-PS NGs may be used as a promising theranostic agent for MR/PA dual-mode imaging-guided PTT of other FAR-expressing tumors.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据