期刊
ACS OMEGA
卷 4, 期 17, 页码 17244-17250出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsomega.9b01865
关键词
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资金
- Portuguese Foundation for Science and Technology (FCT)
- FEDER through COMPETE 2020 [POCI-01-0145-FEDER-PTDC/QEQ-MED/0262/2014]
- PT 2020/CENTRO 2020 [CENTRO-01-0145-FEDER-000014/MATIS]
- CIMAGO
- [POCI-01-0145-FEDER-007630]
- [PEst-UID/NEU/04539/2013]
- [POCI-01-0145-FEDER-007440]
Ring-fused diphenylchlorins as potent low-dose photo-sensitizers for photodynamic therapy of bladder carcinoma and esophageal adenocarcinoma are described. All studied molecules were very active against HT1376 urinary bladder carcinoma and OE19 esophageal adenocarcinoma cell lines, showing IC50 values below 50 nM. The in vivo evaluation of the more promising photosensitizer, using an OE19 tumor/chick embryo chorioallantoic membrane model, showed a tumor weight regression of 33% with a single photodynamic therapy treatment with the photosensitizer dose as low as 37 ng/embryo.
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