期刊
ACS OMEGA
卷 4, 期 18, 页码 17923-17933出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsomega.9b03109
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资金
- VPRs Office at Oklahoma State University
- College of Arts and Sciences at Oklahoma State University
- Department of Chemistry at Oklahoma State University
- American Chemical Society Petroleum Research Fund (ACS PRF Doctoral New Investigator (DNI) Research Grant) [58507 DNI-1]
1,4-Diaryl- and 1-aryl-4-alkyl-substituted 1,2,4-triazolium salts are convenient air-stable precursors to carbenes used both as organocatalysts or as ligands for transition metal complexes. Traditionally, they are prepared via a multistep synthetic pathway with the low-yielding formation of the triazolium ring occurring in the last step. We have developed an alternative two-step synthesis involving the conversion of a primary amine or aniline derivative to the corresponding 4-substituted triazole followed by a copper-catalyzed arylation with diaryliodonium salts. This transition metal-catalyzed arylation can be carried out under mild conditions in acetonitrile and is tolerant toward both water and oxygen. Additionally, the high functional group tolerance of the protocol described here gives easy access to triazolium salts containing heterocyclic substituents or sulfides.
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