Effect of piperine on size, shape and morphology of hydroxyapatite nanoparticles synthesized by the chemical precipitation method

The role of piperine, a water insoluble alkaloid compound on the nucleation, crystallinity, size, shape and dispersion of hydroxyapatite (HAp) nanoparticles was investigated. Two different concentrations of piperine were used as an organic modifier. FTIR spectra support the transformation of functional groups. The XRD pattern reveals the crystalline nature of the materials. The TEM images disclose the mechanism of nucleation, formation, shape, size and morphology of HAp nanorods. The addition of the piperine during the synthesis altered the morphology of HAp nanorods. Piperine, as water insoluble alkaloid could affect the morphology of the HAp nanoparticles with agglomeration. These types of well defined and shaped HAp nanorods can be used as a delivery service for drug release and in the field of biomaterial research. (C) 2018 Production and hosting by Elsevier B.V. on behalf of King Saud University.