4.6 Article

Fluorescent fullerene nanoparticle-based lateral flow immunochromatographic assay for rapid quantitative detection of C-reactive protein

期刊

NANO CONVERGENCE
卷 6, 期 1, 页码 -

出版社

SPRINGEROPEN
DOI: 10.1186/s40580-019-0207-0

关键词

Fullerene; Nanoparticle; C-reactive protein; Lateral flow immunochromatographic assay; Fluorescence

资金

  1. Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Science and ICT (MSIT) [NRF-2019R1C1C1006084, NRF-2019R1C1C1006867]
  2. Center for BioNano Health-Guard - MSIT of Korea as Global Frontier Project [H-GUARD_2013M3A6B2078950]
  3. Bio and Medical Technology Development Program of the NRF - MSIT of Korea [NRF-2018M3A9E2022821]
  4. KRIBB Research Initiative Program
  5. National Research Council of Science & Technology (NST), Republic of Korea [KGM5321911] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

向作者/读者索取更多资源

A fluorescent fullerene nanoparticle (NP)-based lateral flow immunochromatographic assay (LFIA) was developed for the rapid and quantitative detection of C-reactive protein (CRP) in serum. The polyclonal CRP-antibody-conjugated fullerene NPs were simply prepared by 1-ethyl-3-(3-dimethyllaminopropyl)-carbodiimide hydrochloride coupling after carboxylation of fluorescent fullerene NPs. By applying the CRP-antibody-conjugated fullerene NPs to a lateral flow test strip, quantitative analysis of CRP in serum was possible at a concentration range of 0.1-10 ng/ml within 15 min. We anticipate that this novel fluorescent fullerene NP-based LFIA can be useful for the rapid and accurate sensing of biological and chemical species, contributing to the disease diagnosis and prognosis, environmental monitoring, and food safety.

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