期刊
MICROORGANISMS
卷 7, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/microorganisms7100429
关键词
herpes simplex virus; herpesvirus; keratitis; ocular therapy; antiviral; acyclovir
类别
资金
- National Institutes of Health RO1 grants [EY029426, AI139768, EY024710]
- NEI core grant [EY001792]
Herpes simplex virus type-1 (HSV-1) is a neurotropic, double-stranded DNA virus that can cause a wide variety of diseases, including many ocular pathologies. It is one of the leading causes of infectious blindness in the United States. Because of its ubiquitous nature and its potential to cause serious ocular maladies, there is a significant need for more effective antiviral therapies against ocular HSV-1. In this review, we discuss the lifecycle of HSV-1 as it pertains to corneal infections and the clinically approved as well as emerging treatments to combat HSV-1 infections. We also highlight some newly identified host targets for the antiviral drug development.
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