期刊
ANTIOXIDANTS
卷 8, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/antiox8090332
关键词
resveratrol; cosmetics; skin lightening; melanin; hypopigmentation; dietary antioxidants; oxidative stress; depigmenting agent; skin aging; phytochemical
资金
- National Research Foundation of Korea (NRF) - Korea government (Ministry of Science and ICT) [2019R1I1A2A01045132]
- Technological Innovation R&D Program of the Ministry of Small and Medium-Sized Enterprises and Startups, Republic of Korea [S2643749]
- Korea Technology & Information Promotion Agency for SMEs (TIPA) [S2643749] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2019R1I1A2A01045132] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Antioxidants are deemed useful in controlling oxidative stress associated with extrinsic skin aging and pigmentation disorders. Resveratrol is a polyphenol compound found in many edible plants such as Vitis vinifera, and its inhibitory effects on the catalytic activity, gene expression, and posttranslational modifications of tyrosinase, a key enzyme in the melanin biosynthetic pathway, provide a mechanistic basis for its antimelanogenic effects seen in melanocytic cells, three-dimensionally reconstituted skin models, and in vivo animal models. As a potent antioxidant and a modulator of nuclear factor erythroid 2-related factor 2 (Nrf2), and sirtuin 1, resveratrol can also regulate multiple signaling pathways associated with inflammation and premature aging. Recent clinical studies have supported the efficacy of resveratrol and its analogs, such as resveratryl triacetate (RTA) and resveratryl triglycolate (RTG), in human skin lightening and antiaging. These findings suggest that resveratrol and its analogs are potentially useful as skin lightening and antiaging agents in cosmetics.
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