期刊
BIOMOLECULES
卷 9, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/biom9120806
关键词
Petasites japonicus; Asteraceae; lignan; anti-inflammation; NO; PGE(2); iNOS; COX-2; molecular docking
资金
- Korea Institute of Planning and Evaluation for Technology in Food, Agriculture and Forestry (IPET) through Agri-Bio Industry Technology Development Program
- Ministry of Agriculture, Food and Rural Affairs (MAFRA), Republic of Korea [116044-1, 118046-03]
- National Research Foundation of Korea (NRF) - Ministry of Science and ICT (MSIT), Republic of Korea [NRF-2019R1A2C1083945]
Two new aryltetralin lactone lignans, petasitesins A and B were isolated from the hot water extract of the leaves of butterbur (Petasites japonicus) along with six known compounds. The chemical structures of lignans 1 and 2 were elucidated on the basis of 1D and 2D nuclear magnetic resonance (NMR) spectroscopic data, electronic circular dichroism (ECD) and vibrational circular dichroism (VCD) spectra. Petasitesin A and cimicifugic acid D showed significant inhibitory effects on the production of both prostaglandin E2 (PGE(2)) and NO in RAW264.7 macrophages. The expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) were inhibited by compound 1 in RAW264.7 cells. Furthermore, compounds 1 and 3 exhibited strong affinities with both iNOS and COX-2 enzymes in molecular docking studies.
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