期刊
VACCINES
卷 7, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/vaccines7040190
关键词
Dermanyssus; poultry red mite; proteomics; vaccine; vaccinology; control; protective antigens
资金
- European Cooperation in Science and Technology (COST), Improving current understanding and research for sustainable control of the poultry red mite Dermanyssus gallinae - COREMI project [FA1404]
- Ministerio de Ciencia, Innovacion y Universidades (Spain)
- Sabiotec SA
- University of Castilla-La Mancha (Spain)
- Doctorado Industrial contract [DI-14-06917]
The poultry red mite (PRM), Dermanyssus gallinae, is a hematophagous ectoparasite considered as the major pest in the egg-laying industry. Its pesticide-based control is only partially successful and requires the development of new control interventions such as vaccines. In this study, we follow a vaccinology approach to identify PRM candidate protective antigens. Based on proteomic data from fed and unfed nymph and adult mites, we selected a novel PRM protein, calumenin (Deg-CALU), which is tested as a vaccine candidate on an on-hen trial. Rhipicephalus microplus Subolesin (Rhm-SUB) was chosen as a positive control. Deg-CALU and Rhm-SUB reduced the mite oviposition by 35 and 44%, respectively. These results support Deg-CALU and Rhm-SUB as candidate protective antigens for the PRM control.
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