期刊
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
卷 7, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fbioe.2019.00326
关键词
self-luminescence; bioluminescence; chemiluminescence; afterglow; deep-tissue imaging; optical imaging
资金
- National Key Research Program of China [2018YFA0208800]
- National Natural Science Foundation of China [81901803, 21503141]
- Jiangsu Specially Appointed Professorship
- Natural Science Foundation of Jiangsu Province [BK20191418, BK20190811, BK20190830]
- Soochow University [GJ12800119, Q412800119]
Optical imaging plays an indispensable role in biology and medicine attributing to its noninvasiveness, high spatiotemporal resolution, and high sensitivity. However, as a conventional optical imaging modality, fluorescence imaging confronts issues of shallow imaging depth due to the need for real-time light excitation which produces tissue autofluorescence. By contrast, self-luminescence imaging eliminates the concurrent light excitation, permitting deeper imaging depth and higher signal-to-background ratio (SBR), which has attracted growing attention. Herein, this review summarizes the progress on the development of near-infrared (NIR) emitting self-luminescence agents in deep-tissue optical imaging with highlighting the design principles including molecular- and nano-engineering approaches. Finally, it discusses current challenges and guidelines to develop more effective self-illuminating agents for biomedical diagnosis and treatment.
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