期刊
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
卷 7, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2019.00308
关键词
autophagy; aging; target of rapamycin; insulin/IGF-1 signaling; proteostasis; DNA damage; mitophagy; anti-aging drugs
资金
- American Federation for Aging Research/Glenn Foundation for Medical Research Postdoctoral Fellowship [PD18019]
- Wellcome Trust Clinical Research Career Development Fellowship
- Rosetrees UCL Excellence Fellowship
- ERC [StG 311331, PoC 842174]
- Royal Society Research Grant
- Bill Lyons Foundation
- CRUK-UCL Centre Award [C416/A25145]
- Medical Research Council [MC_U12266B]
- MRC [MR/M02492X/1, MC_EX_G0800785] Funding Source: UKRI
Autophagy is a major cellular recycling process that delivers cellular material and entire organelles to lysosomes for degradation, in a selective or non-selective manner. This process is essential for the maintenance of cellular energy levels, components, and metabolites, as well as the elimination of cellular molecular damage, thereby playing an important role in numerous cellular activities. An important function of autophagy is to enable survival under starvation conditions and other stresses. The majority of factors implicated in aging are modifiable through the process of autophagy, including the accumulation of oxidative damage and loss of proteostasis, genomic instability and epigenetic alteration. These primary causes of damage could lead to mitochondrial dysfunction, deregulation of nutrient sensing pathways and cellular senescence, finally causing a variety of aging phenotypes. Remarkably, advances in the biology of aging have revealed that aging is a malleable process: a mild decrease in signaling through nutrient-sensing pathways can improve health and extend lifespan in all model organisms tested. Consequently, autophagy is implicated in both aging and age-related disease. Enhancement of the autophagy process is a common characteristic of all principal, evolutionary conserved anti-aging interventions, including dietary restriction, as well as inhibition of target of rapamycin (TOR) and insulin/IGF-1 signaling (IIS). As an emerging and critical process in aging, this review will highlight how autophagy can be modulated for health improvement.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据