期刊
BIOPOLYMERS
卷 104, 期 4, 页码 317-322出版社
WILEY-BLACKWELL
DOI: 10.1002/bip.22651
关键词
transmembrane receptor; juxtamembrane; signal transduction; proteinlipid interaction
资金
- National Institutes of Health [GM084175, HL082808]
Signaling across the cell membrane mediated by transmembrane receptors plays an important role in diverse biological processes. Recent studies have indicated that, in a number of single-span transmembrane receptors, the intracellular juxtamembrane (JM) sequence linking the transmembrane helix with the rest of the cytoplasmic domain participates directly in the signaling process via several novel mechanisms. This review briefly highlights several modes of JM dynamics in the context of signal transduction that are shared by different types of transmembrane receptors. (C) 2015 Wiley Periodicals, Inc.
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