期刊
FRONTIERS IN ONCOLOGY
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2019.01227
关键词
nanoparticles; delivery; tumor; vessel; normalization
类别
资金
- College of Pharmacy, University of Louisiana Monroe
- National Institutes of Health (NIH) through the National Institute of General Medical Science [5 P20 GM103424-15, 3 P20 GM103424-15S1]
- National Institutes of Health Grant (NCI) [R15CA231339]
- Texas Tech University Health Sciences Center (TTUHSC) School of Pharmacy Startup funds
- TTUHSC Office of Research grant
Tumor-induced angiogenesis has been a significant focus of anti-cancer therapies for several decades. The immature and leaky tumor vasculature leads to significant cancer cell intravasation, increasing the metastatic potential, while the disoriented and hypo-perfused tumor vessels hamper the anti-tumor efficacy of immune cells and prevent the efficient diffusion of chemotherapeutic drugs. Therefore, tumor vascular normalization has emerged as a new treatment goal, aiming to provide a mature tumor vasculature, with higher perfusion, decreased cancer cell extravasation, and higher efficacy for anti-cancer therapies. Here we propose an overview of the nanodelivery approaches that target tumor vasculature, aiming to achieve vascular normalization. At the same time, abnormal vascular architecture and leaky tumor vessels have been the cornerstone for nanodelivery approaches through the enhanced permeability and retention (EPR) effect. Vascular normalization presents new opportunities and requirements for efficient nanoparticle delivery against the tumor cells and overall improved anti-cancer therapies.
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