期刊
CELLS
卷 8, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/cells8121542
关键词
gliomas; protein synthesis; translation; cap-dependent; IRES
类别
资金
- Neurological Foundation of New Zealand
- National Fund for Scientific Research (F.N.R.S)
- Televie sub-organization
- Special Funds of the University of Liege
- Anti-Cancer Centre Leon Fredericq Foundation
- NanoFar (Erasmus Mundus, European doctorate in nanomedicine and pharmaceutical innovation)
Cancer cells are continually exposed to environmental stressors forcing them to adapt their protein production to survive. The translational machinery can be recruited by malignant cells to synthesize proteins required to promote their survival, even in times of high physiological and pathological stress. This phenomenon has been described in several cancers including in gliomas. Abnormal regulation of translation has encouraged the development of new therapeutics targeting the protein synthesis pathway. This approach could be meaningful for glioma given the fact that the median survival following diagnosis of the highest grade of glioma remains short despite current therapy. The identification of new targets for the development of novel therapeutics is therefore needed in order to improve this devastating overall survival rate. This review discusses current literature on translation in gliomas with a focus on the initiation step covering both the cap-dependent and cap-independent modes of initiation. The different translation initiation protagonists will be described in normal conditions and then in gliomas. In addition, their gene expression in gliomas will systematically be examined using two freely available datasets. Finally, we will discuss different pathways regulating translation initiation and current drugs targeting the translational machinery and their potential for the treatment of gliomas.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据