相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Non-alcoholic fatty liver disease is associated with dysregulated bile acid synthesis and diarrhea: A prospective observational study
Richard N. Appleby et al.
PLOS ONE (2019)
Ablation of gut microbiota alleviates obesity-induced hepatic steatosis and glucose intolerance by modulating bile acid metabolism in hamsters
Lulu Sun et al.
ACTA PHARMACEUTICA SINICA B (2019)
Therapeutic effects of curcumin and ursodexycholic acid on non-alcoholic fatty liver disease
Shahsanam Gheibi et al.
BIOMEDICINE & PHARMACOTHERAPY (2019)
Apical sodium-dependent bile acid transporter inhibition with volixibat improves metabolic aspects and components of nonalcoholic steatohepatitis in Ldlr-/-.Leiden mice
Kanita Salic et al.
PLOS ONE (2019)
Bile Acid and Fibroblast Growth Factor 19 Regulation in Obese Diabetics, and Non-Alcoholic Fatty Liver Disease after Sleeve Gastrectomy
Hsien-Hao Huang et al.
JOURNAL OF CLINICAL MEDICINE (2019)
A novel ASBT inhibitor, IMB17-15, repressed nonalcoholic fatty liver disease development in high-fat diet-fed Syrian golden hamsters
Mao-xu Ge et al.
ACTA PHARMACOLOGICA SINICA (2019)
Serum bile acid patterns are associated with the presence of NAFLD in twins, and dose-dependent changes with increase in fibrosis stage in patients with biopsy-proven NAFLD
Cyrielle Caussy et al.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2019)
Intestinal TGR5 agonism improves hepatic steatosis and insulin sensitivity in Western diet-fed mice
Patricia D. Finn et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2019)
Green tea polyphenol (epigallocatechin-3-gallate) improves gut dysbiosis and serum bile acids dysregulation in high-fat diet-fed mice
Chihiro Ushiroda et al.
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION (2019)
Suppressed hepatic bile acid signalling despite elevated production of primary and secondary bile acids in NAFLD
Na Jiao et al.
GUT (2018)
INT-767 prevents NASH and promotes visceral fat brown adipogenesis and mitochondrial function
Paolo Comeglio et al.
JOURNAL OF ENDOCRINOLOGY (2018)
Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: Implications for liver transplantation
Zobair M. Younossi
LIVER TRANSPLANTATION (2018)
Bile acid regulation: A novel therapeutic strategy in non-alcoholic fatty liver disease
Qinwei Yu et al.
PHARMACOLOGY & THERAPEUTICS (2018)
G-Protein-Coupled Bile Acid Receptor Plays a Key Role in Bile Acid Metabolism and Fasting-Induced Hepatic Steatosis in Mice
Ajay C. Donepudi et al.
HEPATOLOGY (2017)
Fibroblast growth factor 15/19 (FGF15/19) protects from diet-induced hepatic steatosis: development of an FGF19-based chimeric molecule to promote fatty liver regeneration
Gloria Alvarez-Sola et al.
GUT (2017)
Bile Acid Alterations Are Associated With Insulin Resistance, but Not With NASH, in Obese Subjects
Vanessa Legry et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2017)
Modulation of the gut microbiota impacts nonalcoholic fatty liver disease: a potential role for bile acids
Aafke W. F. Janssen et al.
JOURNAL OF LIPID RESEARCH (2017)
Interactions between gut bacteria and bile in health and disease
Sarah L. Long et al.
MOLECULAR ASPECTS OF MEDICINE (2017)
A novel class of apical sodium-dependent bile salt transporter inhibitors: 1-(2,4-bifluoropheny1)-7-dialkylamino-1,8-naphthyridine-3-carboxamides
Hongtao Liu et al.
ACTA PHARMACEUTICA SINICA B (2017)
Beneficial effects of combined ursodeoxycholic acid and angiotensin-II type 1 receptor blocker on hepatic fibrogenesis in a rat model of nonalcoholic steatohepatitis
Tadashi Namisaki et al.
JOURNAL OF GASTROENTEROLOGY (2016)
The intrahepatic expression levels of bile acid transporters are inversely correlated with the histological progression of nonalcoholic fatty liver disease
Kazuya Okushin et al.
JOURNAL OF GASTROENTEROLOGY (2016)
Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD
Alexandra Montagner et al.
GUT (2016)
Vertical sleeve gastrectomy activates GPBAR-1/TGR5 to sustain weight loss, improve fatty liver, and remit insulin resistance in mice
Lili Ding et al.
HEPATOLOGY (2016)
Activation of Transmembrane Bile Acid Receptor TGR5 Modulates Pancreatic Islet Cells to Promote Glucose Homeostasis
Divya P. Kumar et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
Metabolic interplay between white, beige, brown adipocytes and the liver
Ludger Scheja et al.
JOURNAL OF HEPATOLOGY (2016)
Discovery of 3α,7α,11β-Trihydroxy-6α-ethyl-5β-cholan-24-oic Acid (TC-100), a Novel Bile Acid as Potent and Highly Selective FXR Agonist for Enterohepatic Disorders
Roberto Pellicciari et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Chenodeoxycholic acid significantly impacts the expression of miRNAs and genes involved in lipid, bile acid and drug metabolism in human hepatocytes
Regina Krattinger et al.
LIFE SCIENCES (2016)
The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)
Elena Buzzetti et al.
METABOLISM-CLINICAL AND EXPERIMENTAL (2016)
Structure and functional characterization of a bile acid 7α dehydratase BaiE in secondary bile acid synthesis
Shiva Bhowmik et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2016)
Fatty liver diseases, bile acids, and FXR
Yan Zhu et al.
ACTA PHARMACEUTICA SINICA B (2016)
Bile Acids and Dysbiosis in Non-Alcoholic Fatty Liver Disease
Marialena Mouzaki et al.
PLOS ONE (2016)
Altered Bile Acid Metabolome in Patients with Nonalcoholic Steatohepatitis
Brian C. Ferslew et al.
DIGESTIVE DISEASES AND SCIENCES (2015)
Fibrates and cholestasis
Nisanne S. Ghonem et al.
HEPATOLOGY (2015)
Nonalcoholic Fatty Liver Disease A Systematic Review
Mary E. Rinella
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2015)
Ursodeoxycholic acid exerts farnesoid X receptor-antagonistic effects on bile acid and lipid metabolism in morbid obesity
Michaela Mueller et al.
JOURNAL OF HEPATOLOGY (2015)
Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial
Brent A. Neuschwander-Tetri et al.
LANCET (2015)
Bile acids and sphingosine-1-phosphate receptor 2 in hepatic lipid metabolism
Eric Kwong et al.
ACTA PHARMACEUTICA SINICA B (2015)
Protective effects of farnesoid X receptor (FXR) on hepatic lipid accumulation are mediated by hepatic FXR and independent of intestinal FGF15 signal
Johannes Schmitt et al.
LIVER INTERNATIONAL (2015)
The Fatty Acid-Bile Acid Conjugate Aramchol Reduces Liver Fat Content in Patients With Nonalcoholic Fatty Liver Disease
Rifaat Safadi et al.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2014)
Adiponectin: A multitasking player in the field of liver diseases
T. E. Silva et al.
DIABETES & METABOLISM (2014)
The bile acid TGR5 membrane receptor: From basic research to clinical application
Henri Duboc et al.
DIGESTIVE AND LIVER DISEASE (2014)
Biosynthesis and trafficking of the bile salt export pump, BSEP: Therapeutic implications of BSEP mutations
Carol J. Soroka et al.
MOLECULAR ASPECTS OF MEDICINE (2014)
Adipocyte cell size, free fatty acids and apolipoproteins are associated with non-alcoholic liver injury progression in severely obese patients
Alexander Wree et al.
METABOLISM-CLINICAL AND EXPERIMENTAL (2014)
Bile acid receptors in non-alcoholic fatty liver disease
Yuanyuan Li et al.
BIOCHEMICAL PHARMACOLOGY (2013)
Systemic bile acid sensing by G protein-coupled bile acid receptor 1 (GPBAR1) promotes PYY and GLP-1 release
C. Ullmer et al.
BRITISH JOURNAL OF PHARMACOLOGY (2013)
Pharmacology, Physiology, and Mechanisms of Incretin Hormone Action
Jonathan E. Campbell et al.
CELL METABOLISM (2013)
Hypoxic liver injury and cholestasis in critically ill patients
Thomas Horvatits et al.
CURRENT OPINION IN CRITICAL CARE (2013)
Free fatty acids repress small heterodimer partner (SHP) activation and adiponectin counteracts bile acid-induced liver injury in superobese patients with nonalcoholic steatohepatitis
Lars P. Bechmann et al.
HEPATOLOGY (2013)
Primary bile acids as potential biomarkers for the clinical grading of intrahepatic cholestasis of pregnancy
Jianbo Chen et al.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS (2013)
Modulation of the fecal bile acid profile by gut microbiota in cirrhosis
Genta Kakiyama et al.
JOURNAL OF HEPATOLOGY (2013)
Bile Acid-Mediated Control of Liver Triglycerides
Claudia Fuchs et al.
SEMINARS IN LIVER DISEASE (2013)
Decreased hepatotoxic bile acid composition and altered synthesis in progressive human nonalcoholic fatty liver disease
April D. Lake et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2013)
Methodologies for Investigating Natural Medicines for the Treatment of Nonalcoholic Fatty Liver Disease (NAFLD)
Moon Sun Kim et al.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2012)
Conjugated bile acids activate the sphingosine-1-phosphate receptor 2 in primary rodent hepatocytes
Elaine Studer et al.
HEPATOLOGY (2012)
Metabolomics reveals an essential role for peroxisome proliferator-activated receptor α in bile acid homeostasis
Fei Li et al.
JOURNAL OF LIPID RESEARCH (2012)
Farnesoid X Receptor Induces Murine Scavenger Receptor Class B Type I via Intron Binding
Guodong Li et al.
PLOS ONE (2012)
Adipokines: A treasure trove for the discovery of biomarkers for metabolic disorders
Stefan Lehr et al.
PROTEOMICS CLINICAL APPLICATIONS (2012)
Adipokines: Biofactors from white adipose tissue. A complex hub among inflammation, metabolism, and immunity
Javier Conde et al.
BIOFACTORS (2011)
The G-Protein-Coupled Bile Acid Receptor, Gpbar1 (TGR5), Negatively Regulates Hepatic Inflammatory Response Through Antagonizing Nuclear Factor Kappa Light-Chain Enhancer of Activated B Cells (NF-κB) in Mice
Yan-Dong Wang et al.
HEPATOLOGY (2011)
Plasma metabolomic profile in nonalcoholic fatty liver disease
Satish C. Kalhan et al.
METABOLISM-CLINICAL AND EXPERIMENTAL (2011)
The membrane-bound bile acid receptor TGR5 (Gpbar-1) is localized in the primary cilium of cholangiocytes
Verena Keitel et al.
BIOLOGICAL CHEMISTRY (2010)
Significance of serum adiponectin levels in patients with chronic liver disease
Maria Luisa Balmer et al.
CLINICAL SCIENCE (2010)
Structure-Activity Relationship Study of Betulinic Acid, A Novel and Selective TGR5 Agonist, and Its Synthetic Derivatives: Potential Impact in Diabetes
Cedric Genet et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
Adipokines in Liver Diseases
Fabio Marra et al.
HEPATOLOGY (2009)
Anti-inflammatory actions of PPAR ligands: new insights on cellular and molecular mechanisms
Daniel S. Straus et al.
TRENDS IN IMMUNOLOGY (2007)
Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine
Insook Kim et al.
JOURNAL OF LIPID RESEARCH (2007)
The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice
B Cariou et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice
YQ Zhang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Budesonide combined with UDCA to improve liver histology in primary biliary cirrhosis:: A three-year randomized trial
H Rautiainen et al.
HEPATOLOGY (2005)
Hepatic overexpression of murine Abcb11 increases hepatobiliary lipid secretion and reduces hepatic steatosis
A Figge et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity
GL Guo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Farnesoid X receptor regulates bile acid-amino acid conjugation
PC Pircher et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Bile acids enhance low density lipoprotein receptor gene expression via a MAPK cascade-mediated stabilization of mRNA
M Nakahara et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Vitamin D receptor as an intestinal bile acid sensor
M Makishima et al.
SCIENCE (2002)
Leptin receptor-mediated signaling regulates hepatic fibrogenesis and remodeling of extracellular matrix in the rat
K Ikejima et al.
GASTROENTEROLOGY (2002)
Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors
TT Lu et al.
MOLECULAR CELL (2000)