期刊
NATURE MICROBIOLOGY
卷 5, 期 1, 页码 27-+出版社
NATURE PORTFOLIO
DOI: 10.1038/s41564-019-0609-0
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资金
- Leading Advanced Projects for medical innovation (LEAP) from the Japan Agency for Medical Research and Development (AMED) [JP18am001007]
- Ministry of Education, Culture, Science, Sports and Technology (MEXT) of Japan [16H06429, 16K21723, 16H06434]
- Japan Initiative for Global Research Network on Infectious Diseases (J-GRID) from AMED [JP19fm0108006]
- Research Program on Emerging and Re-emerging Infectious Diseases from AMED [JP19fk0108031, JP19fk0108056, JP19fk0108058, JP19fk0108066]
- NIAID-funded Center for Research on Influenza Pathogenesis (CRIP) [HHSN272201400008C]
Here we report the isolation of the influenza A/H1N1 2009 pandemic (A/H1N1pdm) and A/H3N2 viruses carrying an I38T mutation in the polymerase acidic protein-a mutation that confers reduced susceptibility to baloxavir marboxil-from patients before and after treatment with baloxavir marboxil in Japan. These variants showed replicative abilities and pathogenicity that is similar to those of wild-type isolates in hamsters; they also transmitted efficiently between ferrets by respiratory droplets.
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