Gold-Catalyzed Reaction of 2H-Tetrazoles with Alkynes: Efficient Route to N-Alkenylated Tetrazoles

A gold-catalyzed reaction of 2H-tetrazoles with alkynes was described for the efficient synthesis of a variety of N-alkenylated tetrazole derivatives, including N-1 and N-2 vinyl functionalized products which are readily isolated by column chromatography. The reaction mechanism was proposed to be a nucleophilic addition process to the alkyne motif activated by gold catalyst. The reaction features mild reaction condition, simple operation and high yields.