期刊
FRONTIERS IN CHEMISTRY
卷 7, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fchem.2019.00723
关键词
Ullmann amination reaction; copper catalysis; deep eutectic solvents; amine synthesis; green chemistry
资金
- national PRIN project Unlocking Sustainable Technologies Through Nature-Inspired Solvents [2017A5HXFC_002]
- Interuniversity Consortium C.I.N.M.P.I.S.
- University of Bari Aldo Moro [CapriatiV.FABR2018SFARMA, PernaF.FABR2018SFARMA, PernaF.18 FondiAteneo15-16, VitaleP.18 FondiAteno15-16, VitaleP.FABR2018SFARMA]
- FSE-FESR [1377]
The CuI-catalyzed Ullmann amine cross-coupling between (hetero)aryl halides (Br, I) and aromatic and aliphatic amines has been accomplished in deep eutectic solvents as environmentally benign and recycling reaction media. Under optimized conditions, the reaction proceeds smoothly under mild conditions (60-100 degrees C) in air, in the absence of ligands, with a catalyst (CuI) loading of 10 mol% and K2CO3 (aliphatic primary and secondary amines) or t-BuOK (aromatic amines) as the base. A variety of amines have been synthesized in yields up to 98% with a broad substrate scope.
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