期刊
NATIONAL SCIENCE REVIEW
卷 7, 期 3, 页码 629-643出版社
OXFORD UNIV PRESS
DOI: 10.1093/nsr/nwz188
关键词
biomaterials; tissue engineering; shape-memory polymer; topographical conversion; endothelialization
资金
- National Key RAMP
- D Program of China [2017YFA0701303]
- National Natural Science Foundation of China [51903245]
- Youth Innovation Promotion Association of CAS
- CAS Key Laboratory of Health Informatics
- Shenzhen Institutes of Advanced Technology
- Special Support Project for Outstanding Young Scholars of Guangdong Province [2015TQ01R292]
- Guangdong-Hong Kong Technology Cooperation Funding [2017A050506040]
- Shenzhen Science and Technology Innovation Committee [JCYJ20180507182051636, KQJSCX20180330170232019, JCYJ20170413152640731]
- Shenzhen Peacock Plan [KQTD20170810160424889]
Endothelialization is of great significance for vascular remodeling, as well as for the success of implanted vascular grafts/stents in cardiovascular disease treatment. However, desirable endothelialization on synthetic biomaterials remains greatly challenging owing to extreme difficulty in offering dynamic guidance on endothelial cell (EC) functions resembling the native extracellular matrix-mediated effects. Here, we demonstrate a bilayer platform with near-infrared-triggered transformable topographies, which can alter the geometries and functions of human ECs by tunable topographical cues in a remote-controlled manner, yet cause no damage to the cell viability. The migration and the adhesion/spreading of human ECs are respectively promoted by the temporary anisotropic and permanent isotropic topographies of the platform in turn, which appropriately meet the requirements of stage-specific EC manipulation for endothelialization. In addition to the potential of promoting the development of a new generation of vascular grafts/stents enabling rapid endothelialization, this stage-specific cell-manipulation platform also holds promise in various biomedical fields, since the needs for stepwise control over different cell functions are common in wound healing and various tissue-regeneration processes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据