期刊
FRONTIERS IN IMMUNOLOGY
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2019.02469
关键词
NK cells; pregnancy; influenza virus; cancer cells; NK repertoire
类别
资金
- Elizabeth and Russell Siegelman Fellowship in Infectious Diseases from the Stanford Child Health Research Institute (CHRI)
- Stanford CHRI post-doctoral fellowship
- CHRI -Stanford Clinical and Translational Science Award [UL1 TR000093]
- National Institutes of Health (NIH) Training Grant: Viral Infections in Children [T32 AI78896-05]
- Smith Family Stanford Graduate Fellowship
- Ruth L. Kirschstein NRSA [1F31HD089675]
- Doris Duke Charitable Foundation [2013099]
- McCormick Faculty Award
- Tasha and John Morgridge Endowed Faculty Scholar in Pediatric Translational Medicine from Stanford CHRI
- Stanford University School of Medicine
- NIH Director's New Innovator Award [DP2AI112193]
- Infrastructure and Opportunity Fund as part of the Stanford Human Immunology Project Consortium (HIPC) [U19AI090019]
- Chan Zuckerberg Biohub
- NIH [U19AI057229]
- NIH/NCRR CTSA award [UL1 RR025744]
Pregnant women are particularly susceptible to complications of influenza A virus infection, which may result from pregnancy-induced changes in the function of immune cells, including natural killer (NK) cells. To better understand NK cell function during pregnancy, we assessed the ability of the two main subsets of NK cells, CD56(dim), and CD56(bright) NK cells, to respond to influenza-virus infected cells and tumor cells. During pregnancy, CD56(dim) and CD56(bright) NK cells displayed enhanced functional responses to both infected and tumor cells, with increased expression of degranulation markers and elevated frequency of NK cells producing IFN-gamma. To better understand the mechanisms driving this enhanced function, we profiled CD56(dim) and CD56(bright) NK cells from pregnant and non-pregnant women using mass cytometry. NK cells from pregnant women displayed significantly increased expression of several functional and activation markers such as CD38 on both subsets and NKp46 on CD56(dim) NK cells. NK cells also displayed diminished expression of the chemokine receptor CXCR3 during pregnancy. Overall, these data demonstrate that functional and phenotypic shifts occur in NK cells during pregnancy that can influence the magnitude of the immune response to both infections and tumors.
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