期刊
FRONTIERS IN IMMUNOLOGY
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2019.02663
关键词
extracellular vesicles; microvesicles; immunosuppression; autoimmune diseases; multiple sclerosis; transplant rejection; type 1 diabetes; graft-vs; -host disease
类别
资金
- RSF [18-75-00090]
- Russian Government Program of Competitive Growth of Kazan Federal University
- Ministry of Science and Higher Education of Russian Federation [17.9783.2017/8.9, 20.5175.2017/6.7]
- Russian Science Foundation [18-75-00090] Funding Source: Russian Science Foundation
The immunosuppressive potential of mesenchymal stem cells has been extensively investigated in many studies in vivo and in vitro. In recent years, a variety preclinical and clinical studies have demonstrated that mesenchymal stem cells ameliorate immune-mediated disorders, including autoimmune diseases. However, to date mesenchymal stem cells have not become a widely used therapeutic agent due to safety challenges, high cost and difficulties in providing long term production. A key mechanism underpinning the immunomodulatory effect of MSCs is the production of paracrine factors including growth factors, cytokines, chemokines, and extracellular vesicles (EVs). MSCs derived EVs have become an attractive therapeutic agent for immunomodulation and treatment of immune-mediated disorders. In addition to many preclinical studies of MSCs derived EVs, their beneficial effects have been observed in patients with both acute graft-vs.-host disease and chronic kidney disease. In this review, we discuss the current findings in the field of MSCs derived EVs-based therapies in immune-mediated disorders and approaches to scale EV production for clinical use.
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